Invention Grant
US07528148B2 Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors
失效
吡唑并[3,4-B]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
- Patent Title: Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors
- Patent Title (中): 吡唑并[3,4-B]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
-
Application No.: US10540371Application Date: 2003-12-19
-
Publication No.: US07528148B2Publication Date: 2009-05-05
- Inventor: David George Allen , Diane Mary Coe , Caroline Mary Cook , Anthony William James Cooper , Michael Dennis Dowle , Christopher David Edlin , Julie Nicole Hamblin , Martin Redpath Johnson , Paul Spencer Jones , Mika Kristian Lindvall , Charlotte Jane Mitchell , Alison Judith Redgrave
- Applicant: David George Allen , Diane Mary Coe , Caroline Mary Cook , Anthony William James Cooper , Michael Dennis Dowle , Christopher David Edlin , Julie Nicole Hamblin , Martin Redpath Johnson , Paul Spencer Jones , Mika Kristian Lindvall , Charlotte Jane Mitchell , Alison Judith Redgrave
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent James M. Kanagy; Stephen Venetianer; Charles M. Kinzig
- Priority: GB0230045.7 20021223; GB0230165.3 20021224; GB0307998.5 20030407
- International Application: PCT/EP03/14867 WO 20031219
- International Announcement: WO2004/056823 WO 20040807
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D491/02 ; C07D498/02 ; C07D513/02 ; C07D515/02 ; A01N43/42 ; A61K31/44
![Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors](/abs-image/US/2009/05/05/US07528148B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl or —(CH2)2OH; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3a is a hydrogen atom (H) or C1-3alkyl; R3 is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which n1 and n2 independently are 1 or 2; and Y is O, S, SO2, or NR4; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
Public/Granted literature
- US20060252790A1 Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors Public/Granted day:2006-11-09
Information query