发明授权
- 专利标题： Tet repressor-based transcriptional regulatory proteins
- 专利标题（中）： 基于阻遏物的转录调控蛋白
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申请号： US10456395申请日： 2003-06-05
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公开(公告)号： US07541446B2公开(公告)日： 2009-06-02
- 发明人: Wolfgang Hillen , Hermann Bujard , Stefanie Urlinger
- 申请人： Wolfgang Hillen , Hermann Bujard , Stefanie Urlinger
- 申请人地址： DE Heidelberg
- 专利权人： Tet Systems Holding GmbH & Co. KG
- 当前专利权人： Tet Systems Holding GmbH & Co. KG
- 当前专利权人地址： DE Heidelberg
- 代理机构： Foley & Lardner LLP
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/63
摘要：
The present invention provides a panel of transcriptional activator fusion proteins which comprises both tetracycline controlled transactivator proteins and reverse tetracycline transactivator proteins. These transactivators have novel phenotypes such as altered basal transcriptional activity in the absence of doxycycline, altered induced transcriptional activity in the presence of doxycycline, or differential induction by tetracycline and analogs of tetracycline.