Invention Grant
- Patent Title: Sulfur-containing naphthalimide derivatives
- Patent Title (中): 含硫萘酰亚胺衍生物
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Application No.: US11263591Application Date: 2005-10-31
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Publication No.: US07541463B2Publication Date: 2009-06-02
- Inventor: Xuhong Qian , Yonggang Li , Yufang Xu , Jian Ding , Liping Lin , Zehong Miao , Hong Zhu , Baoyuan Qu
- Applicant: Xuhong Qian , Yonggang Li , Yufang Xu , Jian Ding , Liping Lin , Zehong Miao , Hong Zhu , Baoyuan Qu
- Applicant Address: CN Shanghai CN Shanghai CN Dalian
- Assignee: East China University of Science and Technology,Shanghai Institute of Materia Medica, Chinese Academy of Science,Dalian University of Technology
- Current Assignee: East China University of Science and Technology,Shanghai Institute of Materia Medica, Chinese Academy of Science,Dalian University of Technology
- Current Assignee Address: CN Shanghai CN Shanghai CN Dalian
- Agency: Dorsey & Whitney LLP
- Priority: CN03116709 20030430
- Main IPC: A61K31/4365
- IPC: A61K31/4365 ; C07D221/18 ; C07D471/06
Abstract:
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
Public/Granted literature
- US20060111367A1 Sulfur-containing naphthalimide derivatives Public/Granted day:2006-05-25
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