发明授权
US07544703B2 Cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein
有权
具有引入其中具有取代或未取代氨基的4-吡啶基烷硫基的环状化合物
- 专利标题: Cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein
- 专利标题(中): 具有引入其中具有取代或未取代氨基的4-吡啶基烷硫基的环状化合物
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申请号: US10587410申请日: 2005-02-17
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公开(公告)号: US07544703B2公开(公告)日: 2009-06-09
- 发明人: Takahiro Honda , Hisashi Tajima , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Takaaki Inaba , Yuriko Takeno
- 申请人: Takahiro Honda , Hisashi Tajima , Kenji Kawashima , Kazuyoshi Okamoto , Minoru Yamamoto , Takaaki Inaba , Yuriko Takeno
- 申请人地址: JP Osaka
- 专利权人: Santen Pharmaceutical Co., Ltd.
- 当前专利权人: Santen Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Osaka
- 代理机构: Frishauf, Holtz, Goodman & Chick, P.C.
- 优先权: JP2004-039862 20040217; JP2004-294347 20040906
- 国际申请: PCT/JP2005/002971 WO 20050217
- 国际公布: WO2005/085201 WO 20050915
- 主分类号: A61K31/4436
- IPC分类号: A61K31/4436 ; C07D213/89
摘要:
A novel cyclic compound having a 4-pyridylalkylthio group having an (un)substituted amino group introduced therein or a salt thereof. They are useful as a medicine. The cyclic compound is a compound represented by the following formula (1), which is useful for the treatment of diseases in which angiogenesis participates. In the following formula (1), ring A represents a benzene ring or a 5- or 6-membered aromatic heterocycle optionally fused with a cycloalkane ring; B represents alkylene; R1 and R2 each represents H, (substituted) aryl, (substituted) heterocyclic group, etc.; R3 and R4 each represents H, (substituted) alkyl, (substituted) cycloalkyl, -Z-R5, etc.; R5 represents (substituted) alkyl, (substituted) aryl, (substituted) heterocyclic group, etc.; X and Y each represents H, etc.; Z represents —CO—, —COO—, —CONR6—, —SO2—, etc.; R6 represents H, etc.; p is 0, 1, or 2; and q is 0 or 1.
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