发明授权
- 专利标题： Penam crystals and process for producing the same
- 专利标题（中）： Penam晶体及其制造方法
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申请号： US10574279申请日： 2004-10-08
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公开(公告)号： US07547777B2公开(公告)日： 2009-06-16
- 发明人: Yoshihisa Tokumaru , Akihiro Shimabayashi
- 申请人： Yoshihisa Tokumaru , Akihiro Shimabayashi
- 申请人地址： JP Osaka-shi JP Tokyo
- 专利权人： Otsuka Chemical Co., Ltd.,Taiho Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Chemical Co., Ltd.,Taiho Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Osaka-shi JP Tokyo
- 代理机构： Kratz, Quintos & Hanson, LLP
- 优先权： JP2003-352723 20031010
- 国际申请： PCT/JP2004/015299 WO 20041008
- 国际公布： WO2005/035538 WO 20050421
- 主分类号： C07D499/00
- IPC分类号： C07D499/00 ; C07D499/04
摘要：
The present invention provides novel 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid benzhydryl ester (TMPB)-acetone crystals for use in the production of 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid 1,1-dioxide benzhydryl ester (TAZB); a process for producing the TMPB-acetone crystals comprising the steps of (A) concentrating a TMPB-containing organic solvent solution, (B) dissolving the resulting concentrate in acetone, and (C) precipitating TMPB-acetone crystals from the acetone solution thus obtained; and a process for producing TAZB comprising the step of reacting the TMPB-acetone crystals with an oxidizing agent.
公开/授权文献
- US20070060559A1 Penam crystals and process for producing the same 公开/授权日：2007-03-15
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