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发明授权
US07550465B2 Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them 失效
吡啶并[3,2-e]吡嗪，它们用作磷酸二酯酶10的抑制剂，以及它们的制备方法

Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
摘要：
The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating diseases of mammals including a human which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 10 activity in the central nervous system. More particularly, the invention relates to the treatment of neurologic and psychiatric disorders, for example psychosis and disorders comprising cognitive deficits as symptoms.
摘要（中）：

本发明涉及吡啶并[3,2-e]吡嗪，其制备方法涉及包含这些化合物的药物制剂和作为磷酸二酯酶10抑制剂的这些化合物的药物用途，作为治疗疾病的活性化合物 包括可以通过使用根据本发明的化合物来抑制中枢神经系统中磷酸二酯酶10活性的人的哺乳动物。 更具体地说，本发明涉及治疗神经和精神疾病，例如精神病和包括认知缺陷的症状作为症状。

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