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29 条记录 (耗时 0.028 秒)

    Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
    1.
    发明授权
    Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them 失效
    吡啶并[3,2-e]吡嗪，它们用作磷酸二酯酶10的抑制剂，以及它们的制备方法

    公开(公告)号：US07550465B2

    公开(公告)日：2009-06-23

    申请号：US11753207

    申请日：2007-05-24

    申请人： Norbert Höfgen ,  Hans Stange ,  Barbara Langen ,  Ute Egerland ,  Rudolf Schindler ,  Thomas Pfeifer ,  Chris Rundfeldt

    发明人： Norbert Höfgen ,  Hans Stange ,  Barbara Langen ,  Ute Egerland ,  Rudolf Schindler ,  Thomas Pfeifer ,  Chris Rundfeldt

    IPC分类号： A61K31/4985

    CPC分类号： C07D471/14

    摘要： The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating diseases of mammals including a human which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 10 activity in the central nervous system. More particularly, the invention relates to the treatment of neurologic and psychiatric disorders, for example psychosis and disorders comprising cognitive deficits as symptoms.

    摘要翻译： 本发明涉及吡啶并[3,2-e]吡嗪，其制备方法涉及包含这些化合物的药物制剂和作为磷酸二酯酶10抑制剂的这些化合物的药物用途，作为治疗疾病的活性化合物 包括可以通过使用根据本发明的化合物来抑制中枢神经系统中磷酸二酯酶10活性的人的哺乳动物。 更具体地说，本发明涉及治疗神经和精神疾病，例如精神病和包括认知缺陷的症状作为症状。

    Pyrido[3,2-e]pyrazines, their use as inhibitors of phospohodiesterase 10, and processes for preparing them
    2.
    发明申请
    Pyrido[3,2-e]pyrazines, their use as inhibitors of phospohodiesterase 10, and processes for preparing them 审中-公开
    吡啶并[3,2-e]吡嗪，它们用作磷酸二酯酶10的抑制剂，以及它们的制备方法

    公开(公告)号：US20090239874A1

    公开(公告)日：2009-09-24

    申请号：US12454537

    申请日：2009-05-19

    申请人： Norbert Hofgen ,  Hans Stange ,  Barbara Langen ,  Ute Egerland ,  Rudolf Schindler ,  Thomas Pfeifer ,  Chris Rundfeldt

    发明人： Norbert Hofgen ,  Hans Stange ,  Barbara Langen ,  Ute Egerland ,  Rudolf Schindler ,  Thomas Pfeifer ,  Chris Rundfeldt

    IPC分类号： A61K31/4985 ,  A61P25/18

    CPC分类号： C07D471/14

    摘要： The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating diseases of mammals including a human which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 10 activity in the central nervous system. More particularly, the invention relates to the treatment of neurologic and psychiatric disorders, for example psychosis and disorders comprising cognitive deficits as symptoms.

    摘要翻译： 本发明涉及吡啶并[3,2-e]吡嗪，其制备方法涉及包含这些化合物的药物制剂和作为磷酸二酯酶10抑制剂的这些化合物的药物用途，作为治疗疾病的活性化合物 包括可以通过使用根据本发明的化合物来抑制中枢神经系统中磷酸二酯酶10活性的人的哺乳动物。 更具体地说，本发明涉及治疗神经和精神疾病，例如精神病和包括认知缺陷的症状作为症状。

    4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
    10.
    发明申请
    4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents 审中-公开
    具有N-氧化物基团的4-，6-或7-羟基吲哚及其作为治疗剂的用途

    公开(公告)号：US20060128758A1

    公开(公告)日：2006-06-15

    申请号：US11342428

    申请日：2006-01-30

    申请人： Nobert Hofgen ,  Hildegard Kuss ,  Karin Steinike ,  Ute Egerland ,  Chris Rundfeldt

    发明人： Nobert Hofgen ,  Hildegard Kuss ,  Karin Steinike ,  Ute Egerland ,  Chris Rundfeldt

    IPC分类号： A61K31/4439 ,  C07D403/14 ,  C07D403/02

    CPC分类号： C07D401/12

    摘要： The invention relates to substituted 4-, 6- or 7-hydroxyindoles with N-oxide groups, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.

    摘要翻译： 本发明涉及具有N-氧化物基团的取代的4-，6-或7-羟基吲哚，其制备方法，包含这些化合物的药物制剂以及作为磷酸二酯酶4的抑制剂的这些化合物的药物用途作为活性成分 用于治疗可受本发明化合物抑制磷酸二酯酶4活性，特别是在免疫活性细胞（例如巨噬细胞和淋巴细胞）中的作用的病症。