发明授权
- 专利标题: Polyamide nucleic acid derivatives and agents, and processes for preparing them
- 专利标题(中): 聚酰胺核酸衍生物和试剂,及其制备方法
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申请号: US11855443申请日: 2007-09-14
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公开(公告)号: US07550582B2公开(公告)日: 2009-06-23
- 发明人: Eugen Uhlmann , Gerhard Breipohl , David William Will
- 申请人: Eugen Uhlmann , Gerhard Breipohl , David William Will
- 申请人地址: DE Frankfurt am Main
- 专利权人: sanofi-aventis Deutschland GmbH
- 当前专利权人: sanofi-aventis Deutschland GmbH
- 当前专利权人地址: DE Frankfurt am Main
- 优先权: DE10019135 20000418
- 主分类号: C07H21/00
- IPC分类号: C07H21/00 ; C07H21/02 ; C07H21/04 ; C12Q1/68
摘要:
The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents.