Invention Grant
- Patent Title: Substituted pyrimidines useful as protein kinase inhibitors
- Patent Title (中): 可用作蛋白激酶抑制剂的取代嘧啶
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Application No.: US11500981Application Date: 2006-08-09
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Publication No.: US07557106B2Publication Date: 2009-07-07
- Inventor: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
- Applicant: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agent H. Joon Chung
- Main IPC: C07D403/14
- IPC: C07D403/14 ; A61K31/4155
Abstract:
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Public/Granted literature
- US20060270660A1 Processes for preparing substituted pyrimidines Public/Granted day:2006-11-30
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