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    Compositions useful as inhibitors of protein kinases
    1.
    发明授权
    Compositions useful as inhibitors of protein kinases 失效
    可用作蛋白激酶抑制剂的组合物

    公开(公告)号：US08642779B2

    公开(公告)日：2014-02-04

    申请号：US12634136

    申请日：2009-12-09

    申请人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    发明人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    IPC分类号： C07D231/54 ,  C07D401/00 ,  C07D409/00

    CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A, B, Q, R1, and R2 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds, and methods of utilizing those compositions in the treatment of various disorders.

    摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，其中A，B，Q，R 1和R 2如说明书中所述。 这些化合物是蛋白激酶的抑制剂，特别是AKT或PDK1激酶的抑制剂，涉及增殖和神经变性疾病的哺乳动物蛋白激酶。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法，以及利用这些组合物治疗各种疾病的方法。

    Compositions Useful As Inhibitors of Protein Kinases
    4.
    发明申请
    Compositions Useful As Inhibitors of Protein Kinases 失效
    可用作蛋白激酶抑制剂的组合物

    公开(公告)号：US20100087467A1

    公开(公告)日：2010-04-08

    申请号：US12634136

    申请日：2009-12-09

    申请人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    发明人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    IPC分类号： A61K31/506 ,  C07D403/14 ,  C07D487/04 ,  A61K31/4162 ,  A61P35/00

    CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A, B, Q, R1, and R2 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds, and methods of utilizing those compositions in the treatment of various disorders.

    摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，其中A，B，Q，R 1和R 2如说明书中所述。 这些化合物是蛋白激酶的抑制剂，特别是AKT或PDK1激酶的抑制剂，涉及增殖和神经变性疾病的哺乳动物蛋白激酶。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法，以及利用这些组合物治疗各种疾病的方法。

    Compositions useful as inhibitors of protein kinases
    5.
    发明授权
    Compositions useful as inhibitors of protein kinases 失效
    可用作蛋白激酶抑制剂的组合物

    公开(公告)号：US07652135B2

    公开(公告)日：2010-01-26

    申请号：US10949714

    申请日：2004-09-23

    申请人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    发明人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    IPC分类号： C07D413/00 ,  C07D211/32

    CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A, B, Q, R1, and R2 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds, and methods of utilizing those compositions in the treatment of various disorders.

    摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，其中A，B，Q，R 1和R 2如说明书中所述。 这些化合物是蛋白激酶的抑制剂，特别是AKT或PDK1激酶的抑制剂，涉及增殖和神经变性疾病的哺乳动物蛋白激酶。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法，以及利用这些组合物治疗各种疾病的方法。

    Compositions useful as inhibitors of protein kinases
    9.
    发明申请
    Compositions useful as inhibitors of protein kinases 失效
    可用作蛋白激酶抑制剂的组合物

    公开(公告)号：US20050101594A1

    公开(公告)日：2005-05-12

    申请号：US10949714

    申请日：2004-09-23

    申请人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    发明人： Hayley Binch ,  Simon Everitt ,  Francesca Mazzei ,  Daniel Robinson

    IPC分类号： A61K31/41 ,  A61K31/4162 ,  A61K31/4745 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A, B, Q, R1, and R2 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds, and methods of utilizing those compositions in the treatment of various disorders.

    摘要翻译： 本发明提供式I化合物或其药学上可接受的衍生物，其中A，B，Q，R 1和R 2如说明书所述。 这些化合物是蛋白激酶的抑制剂，特别是AKT或PDK1激酶的抑制剂，涉及增殖和神经变性疾病的哺乳动物蛋白激酶。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法，以及利用这些组合物治疗各种疾病的方法。