利索-全球专利检索

  1. 登录
  2. 注册
发明授权
US07557113B2 Substituted pyrrolo[3,2-d]pyrimidine derivatives 失效
取代的吡咯并[3,2-d]嘧啶衍生物

Substituted pyrrolo[3,2-d]pyrimidine derivatives
摘要：
A compound having GSK-3 inhibitory activity. A1 and A3 are a single bond, an aliphatic hydrocarbon group; A2 and A4 are a single bond, CO, COO, CONR, O, OCO, NR, NRCO, NRCOO, etc.; G1 is a single bond, an aliphatic hydrocarbon, aromatic hydrocarbon, heterocyclic; G2 is H, an aliphatic hydrocarbon, an alicyclic hydrocarbon, an aromatic hydrocarbon, heterocyclic; A5 is a single bond, NR; R2 is H, halogen, an aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; A6 is a single bond, NR, CO, NRCO, NRCONR, CONR, COO, O, etc.; R3 is H, halogen, nitro, saturated aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; and R3 may be a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbamoyl, or cyano group when A6 is CR═CR or C≡C, wherein R is H or an lower aliphatic hydrocarbon group.
摘要（中）：

具有GSK-3抑制活性的化合物。 A1和A3是单键，脂族烃基; A2和A4是单键，CO，COO，CONR，O，OCO，NR，NRCO，NRCOO等; G1是单键，脂族烃，芳烃，杂环; G 2是H，脂族烃，脂环烃，芳烃，杂环; A5是单键，NR; R2是H，卤素，脂族烃，脂环族烃，芳烃，杂环; A6是单键，NR，CO，NRCO，NRCONR，CONR，COO，O等; R3是H，卤素，硝基，饱和脂肪烃，脂环族烃，芳烃，杂环; 当A6是CR-CR或C≡C时，R3可以是三甲基甲硅烷基，甲酰基，酰基，羧基，烷氧基羰基，氨基甲酰基，烷基氨基甲酰基或氰基，其中R是H或低级脂族烃基。

公开/授权文献
信息查询
Espacenet
0/0