Invention Grant
US07560558B2 Compound having TGFβ inhibitory activity and medicinal composition containing the same
失效
具有TGFbeta抑制活性的化合物和含有它们的药物组合物
- Patent Title: Compound having TGFβ inhibitory activity and medicinal composition containing the same
- Patent Title (中): 具有TGFbeta抑制活性的化合物和含有它们的药物组合物
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Application No.: US10525087Application Date: 2003-08-22
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Publication No.: US07560558B2Publication Date: 2009-07-14
- Inventor: Kiyoshi Shimizu , Toshiyuki Shimizu , Kaname Kimura , Kazuki Kawakami , Masayoshi Nakoji
- Applicant: Kiyoshi Shimizu , Toshiyuki Shimizu , Kaname Kimura , Kazuki Kawakami , Masayoshi Nakoji
- Applicant Address: JP Tokyo-to
- Assignee: Kirin Beer Kabushiki Kaisha
- Current Assignee: Kirin Beer Kabushiki Kaisha
- Current Assignee Address: JP Tokyo-to
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- Priority: JP2002-244028 20020823
- International Application: PCT/JP03/10647 WO 20030822
- International Announcement: WO2004/018430 WO 20040304
- Main IPC: C07D215/44
- IPC: C07D215/44 ; C07D239/72
Abstract:
The present invention provides compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein X represents CH or N; Z represents —O—, —NH— or —C(═O)—; R and R′ represent a hydrogen atom, hydroxyl, a halogen atom, optionally substituted alkyl, optionally substituted alkenyl optionally substituted alkoxy, amino, aminocarbonyl, or an optionally substituted heterocyclic group; and A represents an optionally substituted specific carbocyclic or heterocyclic group. The compounds according to the present invention have excellent TGFβ inhibitory activity.
Public/Granted literature
- US20060111375A1 Compound having tgfß inhibitory activity and medicinal composition containing the same Public/Granted day:2006-05-25
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