发明授权
US07563811B2 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
有权
1,2-二氢吡啶化合物及其制备方法和用途
- 专利标题： 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof
- 专利标题（中）： 1,2-二氢吡啶化合物及其制备方法和用途
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申请号： US11174514申请日： 2005-07-06
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公开(公告)号： US07563811B2公开(公告)日： 2009-07-21
- 发明人: Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terence Smith
- 申请人： Satoshi Nagato , Kohshi Ueno , Koki Kawano , Yoshihiko Norimine , Koichi Ito , Takahisa Hanada , Masataka Ueno , Hiroyuki Amino , Makoto Ogo , Shinji Hatakeyama , Yoshio Urawa , Hiroyuki Naka , Anthony John Groom , Leanne Rivers , Terence Smith
- 申请人地址： JP Bunkyo-ku
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： JP Bunkyo-ku
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2000-175966 20000612; GB0022483.2 20000913
- 主分类号： C07D401/02
- IPC分类号： C07D401/02 ; A61K31/44
摘要：
The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).