发明授权
- 专利标题： Substituted aminoethers for the treatment of Alzheimer's disease
- 专利标题（中）： 用于治疗阿尔茨海默病的取代氨基醚
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申请号： US10527294申请日： 2003-09-10
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公开(公告)号： US07566730B2公开(公告)日： 2009-07-28
- 发明人: James P. Beck , Matthew Drowns , Martha A. Warpehoski
- 申请人： James P. Beck , Matthew Drowns , Martha A. Warpehoski
- 申请人地址： US CA South San Francisco
- 专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请： PCT/US03/28388 WO 20030910
- 国际公布： WO2004/024675 WO 20040325
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07C239/00 ; C07D277/30 ; C07D213/81 ; C07D401/00 ; C07D239/42 ; A61K31/16
摘要：
The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.