发明授权
US07569689B2 Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
有权
糖皮质激素受体，AP-1和/或NF-κB活性的调节剂及其用途
- 专利标题： Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
- 专利标题（中）： 糖皮质激素受体，AP-1和/或NF-κB活性的调节剂及其用途
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申请号： US11034652申请日： 2005-01-13
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公开(公告)号： US07569689B2公开(公告)日： 2009-08-04
- 发明人: Jingwu Duan , Bin Jiang , James Sheppeck , John L. Gilmore
- 申请人： Jingwu Duan , Bin Jiang , James Sheppeck , John L. Gilmore
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Laurelee A. Duncan
- 主分类号： A61K31/498
- IPC分类号： A61K31/498 ; C07D417/14
摘要：
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least two of X1-X4 and/or X5-X8 is N or NR18, and R, Ra, Rb, Rc, Rd, R1, R2 and R18 are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.