发明授权
- 专利标题： Method of measuring neprilysin activity
- 专利标题（中）： 测定尿蛋白活性的方法
-
申请号： US10512588申请日： 2003-04-24
-
公开(公告)号： US07572574B2公开(公告)日： 2009-08-11
- 发明人: Takaomi Saido , Nobuhisa Iwata , Satoshi Tsubuki , Yoshie Takaki , Takashi Saito , Tadashi Nakaya
- 申请人： Takaomi Saido , Nobuhisa Iwata , Satoshi Tsubuki , Yoshie Takaki , Takashi Saito , Tadashi Nakaya
- 申请人地址： JP Saitama JP Osaka
- 专利权人： Riken,Takeda Pharmaceutical Company, Ltd
- 当前专利权人： Riken,Takeda Pharmaceutical Company, Ltd
- 当前专利权人地址： JP Saitama JP Osaka
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 David G. Conlin; Melissa Hunter-Ensor, Esq.
- 优先权： JP2002-126257 20020426; JP2002-261250 20020906
- 国际申请： PCT/JP03/05239 WO 20030424
- 国际公布： WO03/091449 WO 20031106
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; G01N33/53 ; G01N33/567 ; G01N33/542 ; G01N33/537
摘要：
The present invention provides a method of measuring the activity of neprilysin, etc. More specifically, the present invention provides a method of measuring the activity of neprilysin in nerve cells; a method of screening a protein, a peptide or a compound enhancing the activity or expression of neprilysin nerve cells by measuring the activity of neprilysin; a method of enhancing the activity or expression of neprilysin; and so on. Thus, the compound enhancing the activity and/or expression of neprilysin, which is obtained by the screening method characterized by using the method of measuring the activity of neprilysin in accordance with the present invention, is useful as a preventive and/or therapeutic agent for Alzheimer's disease. The method of measuring the activity of the present invention can be used for presymptoms diagnosis of Alzheimer's disease.
公开/授权文献
- US20060008842A1 Method of measuring neprilysin activity 公开/授权日：2006-01-12
信息查询
