发明授权
- 专利标题： Pyrimidine derivatives for treatment of hyperproliferative disorders
- 专利标题（中）： 嘧啶衍生物用于治疗过度增殖性疾病
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申请号： US10573227申请日： 2004-10-08
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公开(公告)号： US07582645B2公开(公告)日： 2009-09-01
- 发明人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
- 申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
- 申请人地址： US CT West Haven
- 专利权人： Bayer Pharmaceuticals Corporation
- 当前专利权人： Bayer Pharmaceuticals Corporation
- 当前专利权人地址： US CT West Haven
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 Barry Kramer; Ralph A. Loren
- 国际申请： PCT/US2004/033430 WO 20041008
- 国际公布： WO2005/035507 WO 20050421
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D409/14 ; C07D413/14 ; A61K31/506 ; A61K31/505 ; A61P35/00
摘要：
Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
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