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公开(公告)号：US07582645B2
公开(公告)日：2009-09-01
申请号：US10573227
申请日：2004-10-08
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/506 , A61K31/505 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US07582646B2
公开(公告)日：2009-09-01
申请号：US11078681
申请日：2005-03-10
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
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公开(公告)号：US07678804B2
公开(公告)日：2010-03-16
申请号：US11078681
申请日：2005-03-10
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y表示芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20100075967A1
公开(公告)日：2010-03-25
申请号：US12550010
申请日：2009-08-28
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianging Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianging Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/5377 , C07D401/12 , C07D239/02 , C07D413/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20050277640A1
公开(公告)日：2005-12-15
申请号：US11078681
申请日：2005-03-10
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/506 , A61K31/5377 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D43/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20070117817A1
公开(公告)日：2007-05-24
申请号：US10573227
申请日：2004-10-08
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yin , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yin , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion
IPC分类号： A61K31/513 , A61K31/506 , C07D403/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20110098301A1
公开(公告)日：2011-04-28
申请号：US11886132
申请日：2006-03-09
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/506 , C07D401/14 , C07D239/48 , C07D403/12 , C07D413/14 , A61K31/496 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14
摘要： Pyrimidine derivatives of formula pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
摘要翻译： 公开并要求保护含有这些化合物的配方药物组合物的嘧啶衍生物和使用这些化合物治疗过度增殖性疾病如癌症的方法。
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![Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors](/abs-image/US/2010/01/19/US07648986B2/abs.jpg.150x150.jpg)
公开(公告)号：US07648986B2
公开(公告)日：2010-01-19
申请号：US11733045
申请日：2007-04-09
申请人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
发明人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
IPC分类号： C07D495/04 , C07D251/16 , C07D413/10 , A61K31/519 , A61K31/5377 , A61K31/53 , A61K31/497 , A61K31/496 , A61K31/498 , A61P9/12 , A61P9/10 , A61P35/04 , A61P11/06 , C07D401/12 , C07D401/14
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物的合成及其作为Rho-激酶抑制剂的用途。 本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。
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公开(公告)号：US20070238741A1
公开(公告)日：2007-10-11
申请号：US11733045
申请日：2007-04-09
申请人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
发明人： Dhanapalan Nagarathnam , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
IPC分类号： A61K31/519 , A61P25/00 , C07D491/00
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物的合成及其作为Rho-激酶抑制剂的用途。 本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。
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公开(公告)号：US20100216789A1
公开(公告)日：2010-08-26
申请号：US12688428
申请日：2010-01-15
申请人： Dhanapalan NAGARATHNAM , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
发明人： Dhanapalan NAGARATHNAM , Uday Khire , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Chunguang Wang , Barry Hart , Olaf Weber , Mark Lynch , Lei Zhang , Lei Wang
IPC分类号： A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/53 , C07D513/04 , A61P9/12 , A61P9/10 , A61P15/10
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译： 公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。 本发明的这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍，以及治疗由Rho-激酶（例如冠心病）介导的其它适应症。
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