发明授权
US07582667B2 Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase
失效
用于抑制β-分泌酶的二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑]化合物
![Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase](/docs/US/2009-09-01/US07582667B2/abs.jpg.600x600.jpg)
- 专利标题： Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase
- 专利标题（中）： 用于抑制β-分泌酶的二氢螺[二苯并[a，d] [7]环烯-5,4'-咪唑]化合物
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申请号： US11710666申请日： 2007-02-23
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公开(公告)号： US07582667B2公开(公告)日： 2009-09-01
- 发明人: Dominick Anthony Quagliato , Patrick Michael Andrae , Yi Fan
- 申请人： Dominick Anthony Quagliato , Patrick Michael Andrae , Yi Fan
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 代理商 Ram W. Sabnis; Scott K. Larsen
- 主分类号： A01N43/50
- IPC分类号： A01N43/50 ; C07D233/00
![Dihydrospiro[dibenzo[a,d][7]annulene-5,4′-imidazol] compounds for the inhibition of beta-secretase](/abs-image/US/2009/09/01/US07582667B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides a 10,11-dihydrospiro[dibenzo[a,d][7]annulene -5,4′-imidazol]-5′(1′H)-one compound of formula I Also provided are methods and compositions for the inhibition of β-secretase (BACE) and the treatment of β-amyloid deposits and neurofibrillary tangles.