发明授权
- 专利标题: 3′-prodrugs of 2′-deoxy-β-L-nucleosides
- 专利标题(中): 2'-脱氧-β-L-核苷的3'-前药
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申请号: US10972695申请日: 2004-10-25
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公开(公告)号: US07585851B2公开(公告)日: 2009-09-08
- 发明人: Martin L. Bryant , Gilles Gosselin , Jean-Louis Imbach
- 申请人: Martin L. Bryant , Gilles Gosselin , Jean-Louis Imbach
- 申请人地址: US MA Cambridge FR Paris IT Cagliari
- 专利权人: Idenix Pharmaceuticals, Inc.,Centre National de la Recherche Scientifique,L'Universite Montpellier II
- 当前专利权人: Idenix Pharmaceuticals, Inc.,Centre National de la Recherche Scientifique,L'Universite Montpellier II
- 当前专利权人地址: US MA Cambridge FR Paris IT Cagliari
- 代理机构: Jones Day
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; C07H19/073 ; C07H19/10
摘要:
The present invention relates to compounds, compositions and methods for the treatment of a host infected with a hepatitis B virus. Specifically, compound and compositions of 3′-esters of 2′-deoxy-β-L-pyrimidine nucleosides are disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents. Compound and compositions of 3′,5′-diesters of 2′-deoxy-β-L-pyrimidine nucleosides are also disclosed, which can be administered either alone or in combination with other anti-hepatitis B agents.
公开/授权文献
- US20050113330A1 3'-Prodrugs of 2'-deoxy-beta-L-nucleosides 公开/授权日:2005-05-26
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