发明授权
US07588778B2 Delivery carrier for targeting to cells expressed with somatostatin receptors
有权
用于靶向生长抑素受体表达的细胞的递送载体
- 专利标题: Delivery carrier for targeting to cells expressed with somatostatin receptors
- 专利标题(中): 用于靶向生长抑素受体表达的细胞的递送载体
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申请号: US10747125申请日: 2003-12-30
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公开(公告)号: US07588778B2公开(公告)日: 2009-09-15
- 发明人: Pei Kan , Ae-June Wang
- 申请人: Pei Kan , Ae-June Wang
- 申请人地址: TW Hsinchu
- 专利权人: Industrial Technology Research Institute
- 当前专利权人: Industrial Technology Research Institute
- 当前专利权人地址: TW Hsinchu
- 代理机构: Bacon & Thomas, PLLC
- 优先权: TW91138147A 20021231
- 主分类号: A61K9/127
- IPC分类号: A61K9/127 ; A61K31/355 ; C07D311/00
摘要:
The present invention relates to a delivery carrier including liposomes or nanoparticles for targeting the cells expressed with somatostatin receptor, consisting of a plurality of liposomes that have one phospholipid bilayer coating, one hydrophilic core and a bioactive substance. The bioactive substance is packaged in the hydrophilic core, or embedded in the phospholipid bilayer, or electrically bound with liposomes as a complex, wherein the phospholipid bilayer coating is conjugated with a plurality of molecules in the outer surface. The molecules recognize the somatostatin receptor in the surface of the target cells and induce receptor-mediated endocytosis.
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