Invention Grant
- Patent Title: ZA loops of bromodomains
- Patent Title (中): 溴结构域的ZA环
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Application No.: US09784553Application Date: 2001-02-16
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Publication No.: US07589167B2Publication Date: 2009-09-15
- Inventor: Ming-Ming Zhou , Aneel K. Aggarwal , Eric Verdin , Melanie Ott
- Applicant: Ming-Ming Zhou , Aneel K. Aggarwal , Eric Verdin , Melanie Ott
- Applicant Address: US CA Irvine US NY New York
- Assignee: J. David Gladstone Institutes,Mt. Sinai School of Medicine
- Current Assignee: J. David Gladstone Institutes,Mt. Sinai School of Medicine
- Current Assignee Address: US CA Irvine US NY New York
- Agency: Klauber & Jackson, LLC
- Main IPC: C07K2/00
- IPC: C07K2/00 ; C07K7/00 ; C07K14/00
Abstract:
The present invention provides the structural determination of a bromodomain determined by NMR spectroscopy. The present invention also provides binding partners for the bromodomain. The present invention further provides the structural determination of the Tat-P/CAF binding complex determined by NMR spectroscopy. In addition, the present invention provides methodology for related drug discovery using high throughput drug screening or structure based rational drug design using the three-dimensional data.
Public/Granted literature
- US20040043378A1 Methods of identifying modulators of bromodomains Public/Granted day:2004-03-04
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