发明授权
- 专利标题: Globular adiponectin variants
- 专利标题(中): 球状脂联素变体
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申请号: US11421055申请日: 2006-05-30
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公开(公告)号: US07592423B2公开(公告)日: 2009-09-22
- 发明人: Jonathan Zalevsky , Duc-Hanh Thi Nguyen , Gregory L. Moore , Sergei A. Ezhevsky , John R. Desjarlais , Arthur J. Chirino , Darian Cash , Matthew J. Bernett
- 申请人: Jonathan Zalevsky , Duc-Hanh Thi Nguyen , Gregory L. Moore , Sergei A. Ezhevsky , John R. Desjarlais , Arthur J. Chirino , Darian Cash , Matthew J. Bernett
- 申请人地址: US CA Monrovia
- 专利权人: Xencor, Inc.
- 当前专利权人: Xencor, Inc.
- 当前专利权人地址: US CA Monrovia
- 代理机构: Morgan Lewis & Bockius LLP
- 主分类号: C07K14/00
- IPC分类号: C07K14/00 ; C07K1/00 ; C07K17/00 ; C07K16/00 ; A61K38/24 ; A61K38/27
摘要:
An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin.
公开/授权文献
- US20060281151A1 Globular Adiponectin Variants 公开/授权日:2006-12-14
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