发明授权
- 专利标题: Heterocyclic inhibitors of MEK and methods of use thereof
- 专利标题(中): MEK的杂环抑制剂及其使用方法
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申请号: US10992612申请日: 2004-11-18
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公开(公告)号: US07598383B2公开(公告)日: 2009-10-06
- 发明人: Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
- 申请人: Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
- 申请人地址: US CO Boulder
- 专利权人: Array Biopharma Inc.
- 当前专利权人: Array Biopharma Inc.
- 当前专利权人地址: US CO Boulder
- 代理机构: Hogan & Hartson LLP
- 代理商 John R. Moore
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/44
摘要:
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specifications. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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