发明授权
- 专利标题: Phenylpiperazine
- 专利标题(中): 苯基哌嗪
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申请号: US12258591申请日: 2008-10-27
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公开(公告)号: US07605162B2公开(公告)日: 2009-10-20
- 发明人: Roelof Van Hes , Johannes A. M. Van der Heijden , Cornelis G. Kruse , Jacobus Tipker , Martinus T. M. Tulp , Gerben M. Visser , Bernard J. Van Vliet
- 申请人: Roelof Van Hes , Johannes A. M. Van der Heijden , Cornelis G. Kruse , Jacobus Tipker , Martinus T. M. Tulp , Gerben M. Visser , Bernard J. Van Vliet
- 申请人地址: NL Weesp
- 专利权人: Solvay Pharmaceuticals
- 当前专利权人: Solvay Pharmaceuticals
- 当前专利权人地址: NL Weesp
- 代理机构: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 优先权: EP99202710 19990823; NL1012888 19990823
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; C07D403/12
摘要:
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia.The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group —(CH2)—p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group —(CH2)q wherein q has the value 2-4, and salts thereof.
公开/授权文献
- US20090143406A1 New Phenylpiperazine 公开/授权日:2009-06-04
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