发明授权
US07605171B2 (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
失效
（3,4-二取代）丙酸羧酸酯作为S1P（Edg）受体激动剂
- 专利标题： (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
- 专利标题（中）： （3,4-二取代）丙酸羧酸酯作为S1P（Edg）受体激动剂
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申请号： US10575790申请日： 2004-12-13
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公开(公告)号： US07605171B2公开(公告)日： 2009-10-20
- 发明人: Vincent J. Colandrea , George A. Doherty , Jeffrey J. Hale , Pei Huo , Irene E. Legiec , Leslie Toth , Petr Vachal , Lin Yan
- 申请人： Vincent J. Colandrea , George A. Doherty , Jeffrey J. Hale , Pei Huo , Irene E. Legiec , Leslie Toth , Petr Vachal , Lin Yan
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Yong Zhao; Valerie J. Camera
- 国际申请： PCT/US2004/041887 WO 20041213
- 国际公布： WO2005/058848 WO 20050630
- 主分类号： A61K31/443
- IPC分类号： A61K31/443 ; A61K31/4245 ; C07D413/04 ; C07D271/06
摘要：
The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.
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