发明授权
- 专利标题: IGF-1R inhibitor
- 专利标题(中): IGF-1R抑制剂
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申请号: US11814753申请日: 2006-01-27
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公开(公告)号: US07605272B2公开(公告)日: 2009-10-20
- 发明人: Yutaka Kanda , Hiromi Ando , Keiko Kawashima , Takamasa Sugita , Masayo Suzuki , Hisashi Tagaya , Tomoyuki Nakazato , Yoshinori Yamashita , Takeshi Takahashi , Shinji Nara , Hiroaki Nakamura
- 申请人: Yutaka Kanda , Hiromi Ando , Keiko Kawashima , Takamasa Sugita , Masayo Suzuki , Hisashi Tagaya , Tomoyuki Nakazato , Yoshinori Yamashita , Takeshi Takahashi , Shinji Nara , Hiroaki Nakamura
- 申请人地址: JP Tokyo
- 专利权人: Kyowa Hakko Kirin Co., Ltd.
- 当前专利权人: Kyowa Hakko Kirin Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Fitzpatrick, Cella, Harper & Scinto
- 优先权: JP2005-020158 20050127
- 国际申请: PCT/JP2006/301341 WO 20060127
- 国际公布: WO2006/080450 WO 20060803
- 主分类号: C07D231/56
- IPC分类号: C07D231/56 ; C07D211/06 ; C07D413/10 ; C07D403/10 ; A61K31/416 ; A61K31/4439 ; A61K31/496 ; A61K31/5355 ; A61K31/5377
摘要:
The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(═O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.
公开/授权文献
- US20090054508A1 IGF-1R INHIBITOR 公开/授权日:2009-02-26