A fluid distribution system comprises a table configured to engage at least two microplates and moveable in an X-Y plane and in a Z direction toward and away from the X-Y plane. The fluid distribution system can comprise a dispensing head that comprises a plurality of dispensing tips adapted to dispense fluid to one or more locations of a microplate. A plate-handling device is provided to selectively pick up and deposit, substantially simultaneously, two or more of the microplates. The fluid distribution system can further comprise an accessory carriage configured to engage a source of fluid and move the source of fluid into a position adjacent the dispensing head in position for the dispensing head to aspirate fluid from the source of the fluid.