Invention Grant
US07622464B2 Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases
有权
用于治疗炎性疾病的吗啉基 - 脲衍生物
- Patent Title: Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases
- Patent Title (中): 用于治疗炎性疾病的吗啉基 - 脲衍生物
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Application No.: US10509162Application Date: 2003-03-27
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Publication No.: US07622464B2Publication Date: 2009-11-24
- Inventor: Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
- Applicant: Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent James P. Rick
- Priority: GB0207434.2 20020328; GB0301608.6 20030124
- International Application: PCT/EP03/03335 WO 20030327
- International Announcement: WO03/082861 WO 20031009
- Main IPC: A61K31/535
- IPC: A61K31/535 ; C07D413/14 ; C07D413/12
Abstract:
Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6-alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.
Public/Granted literature
- US20060063765A1 Novel compounds Public/Granted day:2006-03-23
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