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1.Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases 有权
标题翻译: 用于治疗炎性疾病的吗啉基 - 脲衍生物公开(公告)号:US07622464B2
公开(公告)日:2009-11-24
申请号:US10509162
申请日:2003-03-27
申请人: Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
发明人: Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
IPC分类号: A61K31/535 , C07D413/14 , C07D413/12
CPC分类号: C07D413/12 , C07D413/14 , C07D417/12
摘要: Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6-alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.
摘要翻译: 式(I)化合物:其中:R 1表示取代或未取代的杂芳基; Y表示 - (CRnaRnb)n-; Rna和Rnb各自独立地为氢或C 1-6烷基; n为0〜5的整数, R2表示未取代或取代的芳基或未取代或取代的杂芳基; R3和R4各自独立地表示氢或C1-6烷基; R 7表示氢或C 1-6烷基; R8代表氢或C1-6烷基; 其盐和溶剂合物; 是CCR3拮抗剂,因此被认为可用于治疗。
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公开(公告)号:US07157457B2
公开(公告)日:2007-01-02
申请号:US10381871
申请日:2001-09-28
申请人: Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
发明人: Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
IPC分类号: A61K31/5375 , C07D265/30
CPC分类号: C07D265/30 , C07D267/10 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要: There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 根据本发明,提供了式(I)的新化合物,其中R 1,R 2,R 3,R 3, 4,R 5,R 6,X,a,b和Z如说明书中所定义,制备方法,含有它们的制剂及其制备方法 用于治疗炎症性疾病。
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3.Morpholin-acetamide derivatives for the treatment of inflammatory diseases 有权
标题翻译: 吗啉 - 乙酰胺衍生物用于治疗炎性疾病公开(公告)号:US07101882B2
公开(公告)日:2006-09-05
申请号:US10381767
申请日:2001-09-28
申请人: Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
发明人: Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
IPC分类号: A61K31/535 , C07D265/30 , A61P29/00
CPC分类号: C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to novel morpholin-acetamide compounds of formula (I) useful for the treatment of inflammatory diseases. Compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 本发明涉及可用于治疗炎性疾病的式(I)的新型吗啉 - 乙酰胺化合物。 式(I)的化合物,其中R 1,R 2,R 3,R 4,R 4, > 5,X,a,b和Z如说明书中所定义,制备方法,含有它们的制剂及其在治疗炎性疾病中的用途。
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4.MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译: 用于治疗炎症性疾病的吗啉 - 乙酰胺衍生物公开(公告)号:US20090163495A1
公开(公告)日:2009-06-25
申请号:US12391855
申请日:2009-02-24
申请人: Rachael Anne Ancliff , Simon Teanby Hodgson , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson
发明人: Rachael Anne Ancliff , Simon Teanby Hodgson , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson
IPC分类号: A61K31/5377 , C07D417/12 , A61P11/06
CPC分类号: C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译: 根据本发明,提供了式(I)的新化合物,其中R 1,R 2,R 3,R 4,R 5,X,a,b和Z如说明书中所定义,其制备方法,含有它们的制剂及其 用于治疗炎症性疾病。
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公开(公告)号:US06534486B1
公开(公告)日:2003-03-18
申请号:US09720193
申请日:2001-02-28
申请人: David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
发明人: David George Allen , Chuen Chan , Caroline Mary Cook , Richard Peter Charles Cousins , Brian Cox , Hazel Joan Dyke , Frank Ellis , Joanna Victoria Geden , Heather Hobbs , Suzanne Elaine Keeling , Alison Judith Redgrave , Stephen Swanson , Caroline Whitworth , David Bays
IPC分类号: A01N4304
CPC分类号: C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/921 , Y10S514/925
摘要: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
摘要翻译: 描述了一系列具有抑制白细胞募集和活化并且是腺苷2a受体激动剂的广泛抗炎性质的2-(嘌呤-9-基) - 四氢呋喃-3,4-二醇衍生物。
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公开(公告)号:US08735390B2
公开(公告)日:2014-05-27
申请号:US13821585
申请日:2011-09-06
申请人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
发明人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Charlotte Jane Mitchell , Nigel James Parr , Robert David Willacy
IPC分类号: A61K31/5377 , C07D413/14
CPC分类号: A61K31/5377 , C07D413/14
摘要: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.
摘要翻译: 本发明涉及作为激酶活性抑制剂的化合物的新型多晶型物和盐。
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公开(公告)号:US20130165433A1
公开(公告)日:2013-06-27
申请号:US13821594
申请日:2011-09-06
申请人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
发明人: Ian Robert Baldwin , Kenneth David Down , Paul Faulder , Simon Gaines , Julie Nicole Hamblin , Zoe Alicia Harrison , Katherine Louise Jones , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Charlotte Jane Mitchell , Nigel James Parr , Timothy John Ritchie , John Edward Robinson , Juliet Kay Simpson , Christopher Alan Paul Smethurst , Yoshiaki Washio
IPC分类号: C07D413/14
CPC分类号: A61K31/5377 , A61K31/416 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5386 , C07D413/14
摘要: The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
摘要翻译: 本发明涉及用于治疗或预防流感病毒感染的化合物。
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公开(公告)号:US20120053166A1
公开(公告)日:2012-03-01
申请号:US13254034
申请日:2010-03-05
申请人: Julie Nicole Hamblin , Zoe Alicia Harrison , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Nigel James Parr
发明人: Julie Nicole Hamblin , Zoe Alicia Harrison , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Christopher James Lunniss , Nigel James Parr
IPC分类号: A61K31/5377 , A61K31/506 , A61K31/454 , A61K31/496 , C07D471/08 , A61K31/4995 , A61K31/538 , C07D417/14 , A61K31/541 , A61K31/553 , A61P11/00 , A61P37/08 , A61P37/00 , A61P29/00 , A61P9/00 , A61P35/00 , A61P25/28 , A61P1/18 , A61P13/12 , A61P7/02 , A61P15/08 , A61P37/06 , A61P25/00 , A61P11/06 , A61P17/00 , A61P1/00 , A61P9/10 , C07D413/14
CPC分类号: C07D413/14 , C07D487/04 , C07D487/08
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
摘要翻译: 本发明涉及某些新化合物。 具体地,本发明涉及式(I)的化合物及其盐。 本发明的化合物是激酶活性的抑制剂,特别是PI3-激酶活性。
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9.6-(1H-indol-4-yl)-4-(5-{[4-1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hemi succinate salt, polymorphs and pharmaceutical compositions thereof 有权
标题翻译: 6-(1H-吲哚-4-基)-4-(5 - {[4-1-甲基乙基] -1-哌嗪基]甲基} -1,3-恶唑-2-基)-1H-吲唑半琥珀酸盐 ,多晶型物及其药物组合物公开(公告)号:US08993576B2
公开(公告)日:2015-03-31
申请号:US13879667
申请日:2011-10-25
申请人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
发明人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr , Robert David Willacy
IPC分类号: A61K31/496 , C07D413/14
CPC分类号: C07D413/14
摘要: The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.
摘要翻译: 本发明涉及一种化合物和化合物的盐及其多晶型物的多晶型物,该化合物是激酶活性的抑制剂。
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公开(公告)号:US08580797B2
公开(公告)日:2013-11-12
申请号:US12768777
申请日:2010-04-28
申请人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
发明人: Julie Nicole Hamblin , Paul Spencer Jones , Suzanne Elaine Keeling , Joelle Le , Nigel James Parr
IPC分类号: A61K31/497 , C07D413/14
CPC分类号: A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/535 , A61K45/06 , C07B2200/13 , C07D413/14 , Y02A50/409
摘要: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.
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