Invention Grant
- Patent Title: Modulators of PPAR and methods of their preparation
- Patent Title (中): PPAR的调节剂及其制备方法
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Application No.: US11202963Application Date: 2005-08-11
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Publication No.: US07622491B2Publication Date: 2009-11-24
- Inventor: Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine M. Gregoire , Vera A. Rakhmanova
- Applicant: Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine M. Gregoire , Vera A. Rakhmanova
- Applicant Address: US CA Hayward
- Assignee: Metabolex Inc.
- Current Assignee: Metabolex Inc.
- Current Assignee Address: US CA Hayward
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A61K31/40
- IPC: A61K31/40 ; A61K31/415 ; C07D207/00 ; C07D231/00 ; C07D233/00

Abstract:
The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.
Public/Granted literature
- US20060058301A1 Modulators of PPAR and methods of their preparation Public/Granted day:2006-03-16
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