发明授权
US07625756B2 Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
有权
2型甘露糖苷酶和III型甘露糖苷酶在低等真核细胞中的表达
- 专利标题： Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
- 专利标题（中）： 2型甘露糖苷酶和III型甘露糖苷酶在低等真核细胞中的表达
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申请号： US10616082申请日： 2003-07-08
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公开(公告)号： US07625756B2公开(公告)日： 2009-12-01
- 发明人: Stephen Hamilton
- 申请人： Stephen Hamilton
- 申请人地址： US NH Lebanon
- 专利权人： GycoFi, Inc.
- 当前专利权人： GycoFi, Inc.
- 当前专利权人地址： US NH Lebanon
- 代理商 John David Reilly; Catherine D. Fitch
- 主分类号： C12N15/70
- IPC分类号： C12N15/70 ; C12N1/15 ; C07K16/00 ; C12N15/63
摘要：
A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is disclosed. Hydrolysis of these linkages on oligosaccharides produces substrates for further N-glycan processing in the secretory pathway.
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