发明授权
![Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists](/docs/US/2009-12-01/US07625905B2/abs.jpg.600x600.jpg)
- 专利标题： Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists
- 专利标题（中）： 八氢吡咯并[3,4-c]吡咯CCR5受体拮抗剂
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申请号： US11901498申请日： 2007-09-18
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公开(公告)号： US07625905B2公开(公告)日： 2009-12-01
- 发明人: Remy Lemoine , Chris Richard Melville , David Mark Rotstein , Jutta Wanner
- 申请人： Remy Lemoine , Chris Richard Melville , David Mark Rotstein , Jutta Wanner
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Brian L. Buckwalter
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545
![Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists](/abs-image/US/2009/12/01/US07625905B2/abs.jpg.150x150.jpg)
摘要：
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R1-R3 and Ar are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I.
公开/授权文献
- US20080103125A1 Heterocylic antiviral compounds 公开/授权日：2008-05-01
信息查询
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