发明授权
US07625946B2 Propargylated aminoindans, processes for preparation, and uses thereof
有权
炔丙基化氨基茚满，制备方法及其应用
- 专利标题： Propargylated aminoindans, processes for preparation, and uses thereof
- 专利标题（中）： 炔丙基化氨基茚满，制备方法及其应用
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申请号： US11710118申请日： 2007-02-23
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公开(公告)号： US07625946B2公开(公告)日： 2009-12-01
- 发明人: Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
- 申请人： Victor Piryatinsky , Bronka Cohen , David Lerner , Dalia Pinkert , Istvan Miskolczi , Yaacov Herzig , Hugo Gottlieb
- 申请人地址： IL Jerusalem
- 专利权人： Yissum Research Development Company of the Hebrew University of Jerusalem
- 当前专利权人： Yissum Research Development Company of the Hebrew University of Jerusalem
- 当前专利权人地址： IL Jerusalem
- 代理机构： Winston & Strawn LLP
- 主分类号： C07C271/10
- IPC分类号： C07C271/10 ; C07C271/16
摘要：
This invention provides compounds having the structure: wherein R1 is methyl and R2 is H, or R1 is ethyl and R2 is hydroxymethyl; R3 is H or propargyl; and R4 is either H or t-butyloxycarbonyl; or an enantiomer or a pharmaceutically acceptable salt thereof. This invention further provides the use of a therapeutically effective amount of such compounds to treat a subject afflicted with a psychiatric disorder, Parkinson's disease, Alzheimer's disease, dementia, or a neurological disorder.
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