发明授权
US07626031B2 Substituted 3-(diarylmethylene)indolin-2-ones and methods of their use
失效
取代的3-（二芳基亚甲基）二氢吲哚-2-酮及其使用方法
- 专利标题： Substituted 3-(diarylmethylene)indolin-2-ones and methods of their use
- 专利标题（中）： 取代的3-（二芳基亚甲基）二氢吲哚-2-酮及其使用方法
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申请号： US10533555申请日： 2003-11-14
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公开(公告)号： US07626031B2公开(公告)日： 2009-12-01
- 发明人: Wei Xu , Erick Wang Co , John M. Nuss , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Amy Lew Tsuhako , Jason Jevious Parks , Zhaoyang Wen , Wei Cheng
- 申请人： Wei Xu , Erick Wang Co , John M. Nuss , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Amy Lew Tsuhako , Jason Jevious Parks , Zhaoyang Wen , Wei Cheng
- 申请人地址： US MD Rockville
- 专利权人： Symphony Evolution, Inc.
- 当前专利权人： Symphony Evolution, Inc.
- 当前专利权人地址： US MD Rockville
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请： PCT/US03/36567 WO 20031114
- 国际公布： WO2004/050681 WO 20040617
- 主分类号： C07D401/00
- IPC分类号： C07D401/00 ; A61K31/445
摘要：
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
公开/授权文献
- US20060122171A1 Kinase modulators 公开/授权日：2006-06-08
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