A low profile card reader is disclosed to include a circuit board with a USB connection interface at the front part, an electrically insulative inner shell bonded to the circuit board outside the USB connection interface and defining an accommodation space, a card connector mounted in the accommodation space and electrically connected to the circuit board for receiving and reading a memory card and having a receiving space for receiving a memory card, a guide member connected to the circuit board and defining a sliding way disposed in line with the receiving space of the card connector for guiding a memory card into the card connector, and an outer metal shielding shell surrounding the circuit board, the electrically insulative inner shell, the card connector and the guide member for EMI protection with the USB connection interface of the circuit board exposed to the outside for connection to a computer.