发明授权
- 专利标题： High performance liquid chromatography with an aqueous mobile phase for analysis of drug and its metabolite
- 专利标题（中）： 用于分析药物及其代谢物的含水流动相的高效液相色谱法
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申请号： US10547751申请日： 2004-03-04
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公开(公告)号： US07632656B2公开(公告)日： 2009-12-15
- 发明人: Hideko Kanazawa , Teruo Okano
- 申请人： Hideko Kanazawa , Teruo Okano
- 申请人地址： JP Tokyo JP Kanagawa
- 专利权人： Cellseed Inc.,Hideko Kanazawa
- 当前专利权人： Cellseed Inc.,Hideko Kanazawa
- 当前专利权人地址： JP Tokyo JP Kanagawa
- 代理机构： Nixon & Vanderhye P.C.
- 优先权： JP2003-104625 20030304
- 国际申请： PCT/JP2004/002753 WO 20040304
- 国际公布： WO2004/078968 WO 20040916
- 主分类号： C12Q1/26
- IPC分类号： C12Q1/26
摘要：
The amount of drug consumption caused by a specific drug-metabolizing enzyme and/or the amount of the resulting metabolite(s) is measured by chromatography with an aqueous mobile phase under temperature control using a packing material whose surface is coated with a polymer having a hydration force varying in the temperature range of 0° C. to 80° C. This system enables proper evaluation of drug-metabolizing capacity through simple means without adversely affecting the environment.
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