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发明授权
US07638505B2 Organophosphoric derivatives useful as anti-parasitic agents 失效
有机磷衍生物可用作抗寄生虫药物

Organophosphoric derivatives useful as anti-parasitic agents
摘要：
The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4 alkoxy, C1-4 alkyl, hydroxy, formyl, trifluoromethoxy, phenyl, heterocyclic, heterocyclic-substituted methyl, aminomethyl, hydroxy methyl, bromomethyl, sulfonyl chloride, acetyl chloride, nitroso and cyano, (b) R1 is selected from the group consisting of hydrogen, C1-7 alkyl, C3-10 cycloalkyl, aryl, arylalkyl and heterocyclic, and (c) R2 is selected from the group consisting of hydroxy and hydroxy-protecting groups, and stereoisomer, solvates and salts thereof. These compounds are useful as anti-infectious and anti-parasitic agents, in particular anti-malaria agents.
摘要（中）：

本发明涉及具有结构式（I）的新型膦酸化合物：其中：（a）R是1至5个独立地选自氟，氯，溴，C1-4烷氧基，C1 -4-烷基，羟基，甲酰基，三氟甲氧基，苯基，杂环，杂环取代的甲基，氨基甲基，羟基甲基，溴甲基，磺酰氯，乙酰氯，亚硝基和氰基，（b）R 1选自氢， 烷基，C 3-10环烷基，芳基，芳烷基和杂环基，和（c）R 2选自羟基和羟基保护基，以及它们的立体异构体，溶剂化物和盐。 这些化合物可用作抗感染和抗寄生虫剂，特别是抗疟剂。

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