A system for compression therapy comprises a patient-support apparatus and a compression sleeve assembly that is coupleable to the patient-support apparatus. In some embodiments, the patient-support apparatus comprises a hospital bed; and in other embodiments, the patient-support apparatus comprises a mattress for a bed. The compression sleeve assembly comprises a sleeve that couples to a patient's limb and that inflates to promote blood flow. The compression sleeve assembly also comprises a conduit and a compression module that is operable to inflate the sleeve through the conduit. The conduit may be routed, at least in part, through the associated patient-support apparatus. The compression module may be situated, at least in part, in a cavity of the associated patient-support apparatus. A compression module that couples to an architectural structure, such as a headwall unit, is also disclosed.