A fluid loss control system having a loss control valve and a plurality of zones including an isolation assembly disposed in a wellbore and a string having a stinger at a downhole most end thereof. The string is supportive of a moveable seal at a selected position uphole of the stinger, the position being calculated to cause engagement of the seal with the isolation assembly and to position the moveable seal to facilitate fluid-flow around the seal when the stinger is engaged with a seal bore of one of the plurality of zones. A method for controlling fluid loss including isolating a fluid column uphole of a pressure seal spaced from the lower completion, opening a fluid loss control valve, stabbing a stinger into a seal bore of the lower completion, and positioning the seal to facilitate fluid flow therearound.