发明授权
- 专利标题: Kit and method for multi-analyte determination
- 专利标题(中): 多分析物测定的试剂盒和方法
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申请号: US12062820申请日: 2008-04-04
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公开(公告)号: US07645612B2公开(公告)日: 2010-01-12
- 发明人: Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
- 申请人: Michael Pawlak , Eginhard Schick , Andreas Peter Abel , Gert Ludwig Duveneck , Markus Ehrat , Gerhard Matthias Kresbach , Eveline Schürmann-Mader , Martin Andreas Bopp
- 申请人地址: DE Leverkusen
- 专利权人: Bayer Technology Services GmbH
- 当前专利权人: Bayer Technology Services GmbH
- 当前专利权人地址: DE Leverkusen
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 优先权: CH1104/00 20000602
- 主分类号: G01N33/543
- IPC分类号: G01N33/543
摘要:
The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.
公开/授权文献
- US20080212070A1 KIT AND METHOD FOR MULTI-ANALYTE DETERMINATION 公开/授权日:2008-09-04
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