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    Flow cell array and the utilization thereof for multianalyte determination
    1.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 有权
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US08053225B2

    公开(公告)日：2011-11-08

    申请号：US12695553

    申请日：2010-01-28

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Kit and method for determining a plurality of analytes
    2.
    发明授权
    Kit and method for determining a plurality of analytes 有权
    用于确定多种分析物的试剂盒和方法

    公开(公告)号：US07396675B2

    公开(公告)日：2008-07-08

    申请号：US10296851

    申请日：2001-05-25

    申请人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    发明人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    IPC分类号： G01N33/543 ,  G01N33/551

    CPC分类号： G01N21/6452 ,  B01L3/5085 ,  G01N21/648 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  Y10S435/808 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808

    摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.

    摘要翻译： 本发明涉及用于同时定性和/或定量测定大量分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导 至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个 由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触 所述测量区域在所述传感器平台上直接或与其它试剂混合之后。 本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

    Kit and method for multi-analyte determination
    3.
    发明授权
    Kit and method for multi-analyte determination 失效
    多分析物测定的试剂盒和方法

    公开(公告)号：US07645612B2

    公开(公告)日：2010-01-12

    申请号：US12062820

    申请日：2008-04-04

    申请人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    发明人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    IPC分类号： G01N33/543

    CPC分类号： G01N21/6452 ,  B01L3/5085 ,  G01N21/648 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  Y10S435/808 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808

    摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.

    摘要翻译： 本发明涉及用于同时定量和/或定量确定多种分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导 至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个 由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触 所述测量区域在所述传感器平台上直接或与其它试剂混合之后。 本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

    Flow cell array and the utilization thereof for multianalyte determination
    4.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 失效
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US07678565B2

    公开(公告)日：2010-03-16

    申请号：US12071526

    申请日：2008-02-21

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Flow cell array and the utilization thereof for multianalyte determination
    5.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 有权
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US07358079B2

    公开(公告)日：2008-04-15

    申请号：US10168001

    申请日：2000-12-13

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样品室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    KIT AND METHOD FOR MULTI-ANALYTE DETERMINATION
    6.
    发明申请
    KIT AND METHOD FOR MULTI-ANALYTE DETERMINATION 失效
    用于多分析确定的套件和方法

    公开(公告)号：US20080212070A1

    公开(公告)日：2008-09-04

    申请号：US12062820

    申请日：2008-04-04

    申请人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schurmann-Mader ,  Martin Andreas Bopp

    发明人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schurmann-Mader ,  Martin Andreas Bopp

    IPC分类号： G01N1/00 ,  G01N21/01 ,  G01J4/00 ,  G01N21/41

    CPC分类号： G01N21/6452 ,  B01L3/5085 ,  G01N21/648 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  Y10S435/808 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808

    摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.

    摘要翻译： 本发明涉及用于同时定量和/或定量确定多种分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导 至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个 由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触 所述测量区域在所述传感器平台上直接或与其它试剂混合之后。 本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

    Device and method for determining multiple analytes
    8.
    发明授权
    Device and method for determining multiple analytes 失效
    用于确定多个分析物的装置和方法

    公开(公告)号：US07708945B1

    公开(公告)日：2010-05-04

    申请号：US10030972

    申请日：2000-08-03

    申请人： Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Eveline Schürmann-Mader

    发明人： Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Eveline Schürmann-Mader

    IPC分类号： G01N21/00 ,  G01N31/22

    CPC分类号： G01N21/648 ,  C12Q1/6816 ,  G01N21/253 ,  G01N21/552 ,  G01N21/7703 ,  G01N33/54373 ,  C12Q2565/628

    摘要： A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement. Each of the sample compartments has different biological or biochemical recognition elements, for the specific recognition and binding of different analytes, immobilized in five or more discrete measurement areas, wherein the measurement areas are in optical interaction with excitation light emanating from the optical waveguide, as part of the sensor platform which forms a demarcation of the sample compartments, and wherein the sample compartments are operable to be cleared from received sample or reagent solutions and to then receive, optionally without washing steps, further sample or reagent solutions, which are supplied to the same sample compartments.

    摘要翻译： 一种装置包括作为传感器平台的一部分的平面光波导，并且直接或通过密封介质连接到平台上的密封层。 密封层直接或通过密封介质形成紧密密封层。 密封层包括至少朝向传感器平台敞开的多个凹部，其以二维布置形成相应的多个样品室。 每个样品室具有不同的生物或生物化学识别元件，用于特异性识别和结合不同分析物，固定在五个或更多个离散测量区域中，其中测量区域与从光波导发出的激发光光学相互作用，如 传感器平台的一部分，其形成样品室的分界，并且其中样品室可操作以从接收的样品或试剂溶液中清除，然后可选地不经过洗涤步骤接收另外的样品或试剂溶液，其被提供给 相同的样品室。

    Device and method for determining multiple analytes
    9.
    发明授权
    Device and method for determining multiple analytes 有权
    用于确定多个分析物的装置和方法

    公开(公告)号：US07927868B2

    公开(公告)日：2011-04-19

    申请号：US12659702

    申请日：2010-03-17

    申请人： Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Eveline Schürmann-Mader

    发明人： Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Eveline Schürmann-Mader

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： G01N21/648 ,  C12Q1/6816 ,  G01N21/253 ,  G01N21/552 ,  G01N21/7703 ,  G01N33/54373 ,  C12Q2565/628

    摘要： A device includes a planar optical waveguide, as part of a sensor platform, and, connected to the platform directly or by means of a sealing medium, a sealing layer. The sealing layer forms either directly or by means of a sealing medium a tightly sealing layer. The sealing layer includes a multitude of recesses at least open towards the sensor platform, which form a corresponding multitude of sample compartments in a 2-dimensional arrangement. Each of the sample compartments has different biological or biochemical recognition elements, for the specific recognition and binding of different analytes, immobilized in five or more discrete measurement areas, wherein the measurement areas are in optical interaction with excitation light emanating from the optical waveguide, as part of the sensor platform which forms a demarcation of the sample compartments, and wherein the sample compartments are operable to be cleared from received sample or reagent solutions and to then receive, optionally without washing steps, further sample or reagent solutions, which are supplied to the same sample compartments.

    摘要翻译： 一种装置包括作为传感器平台的一部分的平面光波导，并且直接或通过密封介质连接到平台上的密封层。 密封层直接或通过密封介质形成紧密密封层。 密封层包括至少朝向传感器平台敞开的多个凹部，其以二维布置形成相应的多个样品室。 每个样品室具有不同的生物或生物化学识别元件，用于特异性识别和结合不同分析物，固定在五个或更多个离散测量区域中，其中测量区域与从光波导发出的激发光光学相互作用，如 传感器平台的一部分，其形成样品室的分界，并且其中样品室可操作以从接收的样品或试剂溶液中清除，然后可选地不经过洗涤步骤接收另外的样品或试剂溶液，其被提供给 相同的样品室。