A method, system and program storage device are provided for machine diagnostics, detection and profiling using pressure waves, the method including profiling known sources, acquiring pressure wave data, analyzing the acquired pressure wave data, and detecting if the analyzed pressure wave data matches a profiled known source; the system including a processor, a pressure wave transducer in signal communication with the processor, a pressure wave analysis unit in signal communication with the processor, and a source or threat detection unit in signal communication with the processor; and the program storage device including program steps for profiling known sources, acquiring pressure wave data, analyzing the acquired pressure wave data, and detecting if the analyzed pressure wave data matches a profiled known source.