发明授权
- 专利标题： Expeditious synthesis of DPD
- 专利标题（中）： 快速合成DPD
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申请号： US11575557申请日： 2005-09-20
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公开(公告)号： US07652172B2公开(公告)日： 2010-01-26
- 发明人: Martin F. Semmelhack , Shawn R. Campagna , Bonnie L. Bassler , Michael J. Federle
- 申请人： Martin F. Semmelhack , Shawn R. Campagna , Bonnie L. Bassler , Michael J. Federle
- 申请人地址： US NJ Princeton
- 专利权人： The Trustees of Princeton University
- 当前专利权人： The Trustees of Princeton University
- 当前专利权人地址： US NJ Princeton
- 代理机构： Volpe and Koenig, P.C.
- 国际申请： PCT/US2005/033648 WO 20050920
- 国际公布： WO2006/034269 WO 20060330
- 主分类号： C07C45/00
- IPC分类号： C07C45/00 ; C07D307/00
摘要：
This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.
公开/授权文献
- US20090018368A1 EXPEDITIOUS SYNTHESIS OF DPD 公开/授权日：2009-01-15
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