发明授权
US07662819B2 Pteridinone derivatives for use as stearoyl CoA desaturase inhibitors
失效
用作硬脂酰CoA去饱和酶抑制剂的蝶啶酮衍生物
- 专利标题： Pteridinone derivatives for use as stearoyl CoA desaturase inhibitors
- 专利标题（中）： 用作硬脂酰CoA去饱和酶抑制剂的蝶啶酮衍生物
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申请号： US11868407申请日： 2007-10-05
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公开(公告)号： US07662819B2公开(公告)日： 2010-02-16
- 发明人: Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
- 申请人： Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Andrew Cole , Tsung Lin , Ian Henderson
- 申请人地址： US CA Foster City
- 专利权人： Gilead Palo Alto, Inc.
- 当前专利权人： Gilead Palo Alto, Inc.
- 当前专利权人地址： US CA Foster City
- 代理商 J. Elin Hartrum
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D475/00 ; A61P35/00 ; A61P3/10 ; A61P9/00
摘要：
The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.