发明授权
- 专利标题: Dermopharmaceutically and cosmetically active oligopeptides
- 专利标题(中): 药物和化妆品活性寡肽
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申请号: US10493856申请日: 2002-10-30
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公开(公告)号: US07671009B2公开(公告)日: 2010-03-02
- 发明人: Christian Ludin , Marc Heidl , Hugo Ziegler
- 申请人: Christian Ludin , Marc Heidl , Hugo Ziegler
- 申请人地址: NL Heerlen
- 专利权人: DSM IP Assets B.V.
- 当前专利权人: DSM IP Assets B.V.
- 当前专利权人地址: NL Heerlen
- 代理机构: Hoffmann & Baron, LLP
- 优先权: CH1986/01 20011030
- 国际申请: PCT/CH02/00587 WO 20021030
- 国际公布: WO03/037933 WO 20030508
- 主分类号: A61K38/00
- IPC分类号: A61K38/00
摘要:
Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) wherein R1 represents H, —C(O)—R7, —SO2—R7, —C(O)—OR7 or —C(O)—N(R7)2 R2 represents, independent of one another, H or —(C1-C4)-alkyl, R3 and R6 represent, independent of one another, —(CH2)q—N(R1)R8 R4 and R5 represent, independent of one another, —CH2—OR2, —CH(CH3)OR8 or —CH2—CH2—OR8 R7 represents hydrogen, optionally substituted (C1-C19)-alkyl; optionally substituted (C1-C19)-alkenyl; phenyl-(C1-C4)-alkyl whose phenyl radical is optionally substituted with amino in the para position R8 represents H, —(C1-C4)-alkyl, —C(O)—R7, —C(O)—OR7, —C(O)—N(R7)2 or —SO2—R7 X represents oxygen (—O—) or —NH—; or XR7, with X=O, also represents the esters of α-tocopherol, tocotrienol or retinol or the carboxylic acid (with R7=H) m, n, p represent, independent of one another, zero or 1 and q in R3 and R6 represent, independent of one another, an integer from 1 to 4, with the provision that the following conditions do not simultaneously occur: R4=—CH(CH3)—OH and R5=—CH(CH3)—OH and R6=—(CH2)4—NH2; dermopharmaceutically and/or cosmetically active compositions containing at least one compound of formula (I).
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