发明授权
- 专利标题: Paclitaxel enhancer compounds
- 专利标题(中): 紫杉醇增强剂化合物
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申请号: US12009641申请日: 2008-01-18
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公开(公告)号: US07671092B2公开(公告)日: 2010-03-02
- 发明人: Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
- 申请人: Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
- 申请人地址: US MA Lexington
- 专利权人: Synta Pharmaceuticals Corp.
- 当前专利权人: Synta Pharmaceuticals Corp.
- 当前专利权人地址: US MA Lexington
- 代理机构: Foley & Lardner LLP
- 代理商 Steven G. Davis
- 主分类号: A61K31/16
- IPC分类号: A61K31/16 ; C07D285/00 ; C07D417/00
摘要:
Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with Paclitaxel or an analog of Paclitaxel.
公开/授权文献
- US20080214655A1 Paclitaxel enhancer compounds 公开/授权日:2008-09-04