Invention Grant
- Patent Title: Conformationally constrained Smac mimetics and the uses thereof
- Patent Title (中): 构象约束的Smac模拟物及其用途
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Application No.: US11632079Application Date: 2005-07-11
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Publication No.: US07674787B2Publication Date: 2010-03-09
- Inventor: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
- Applicant: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- International Application: PCT/US2005/024530 WO 20050711
- International Announcement: WO2006/010118 WO 20060126
- Main IPC: C07D223/16
- IPC: C07D223/16 ; A01N43/00 ; A61K31/55
Abstract:
The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Public/Granted literature
- US20080132485A1 Conformationally Constrained Smac Mimetics And The Uses Thereof Public/Granted day:2008-06-05
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