Invention Grant
- Patent Title: Butanoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof
- Patent Title (中): 丁酸衍生物，其制备方法，包含它们的药物组合物及其治疗应用
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Application No.: US11579362Application Date: 2005-04-06
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Publication No.: US07678831B2Publication Date: 2010-03-16
- Inventor: Jean Jacques Zeiller , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
- Applicant: Jean Jacques Zeiller , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano, Branigan, P.C.
- Priority: FR0404711 20040503
- International Application: PCT/EP2005/003607 WO 20050406
- International Announcement: WO2005/105764 WO 20051110
- Main IPC: A61K31/19
- IPC: A61K31/19 ; C07C65/00
Abstract:
Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the preparation of these compounds. Compounds of formula (I) are activators of PPARα and PPARα isoforms.
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