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1.发明授权Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes 失效丁烯酸衍生物，其制备方法，包含它们的药物组合物和用于治疗血脂异常，动脉粥样硬化和糖尿病的用途公开(公告)号：US08247448B2
公开(公告)日：2012-08-21
申请号：US12821384
申请日：2010-06-23
Applicant: Jean-Jacques Zeiller , Hervé Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
Inventor： Jean-Jacques Zeiller , Hervé Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
IPC: A61K31/235 , A61K31/19
CPC classification number: C07C59/68 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/736
Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
Abstract translation: 本发明涉及式I的丁烯酸衍生物：其中R，R 1，R 2和R 3如说明书中所定义，以及其制备方法，包含它们的药物组合物及其用于治疗的用途 血脂异常，动脉粥样硬化和糖尿病。
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2.发明授权Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia, atherosclerosis and diabetes 失效丁烯酸衍生物，其制备方法，包含它们的药物组合物和用于治疗血脂异常，动脉粥样硬化和糖尿病公开(公告)号：US07820847B2
公开(公告)日：2010-10-26
申请号：US10566995
申请日：2004-07-14
Applicant: Jean-Jacques Zeiller , Hervé Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
Inventor： Jean-Jacques Zeiller , Hervé Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
CPC classification number: C07C59/68 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/736
Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
Abstract translation: 本发明涉及式I的丁烯酸衍生物：其中R，R 1，R 2和R 3如说明书中所定义，以及其制备方法，包含它们的药物组合物及其用于治疗的用途 血脂异常，动脉粥样硬化和糖尿病。
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3.发明申请Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and use for the treatment of dyslipidaemia, atherosclerosis and diabetes 失效丁烯酸衍生物，其制备方法，包含它们的药物组合物和用于治疗血脂异常，动脉粥样硬化和糖尿病的用途公开(公告)号：US20100261789A1
公开(公告)日：2010-10-14
申请号：US12821384
申请日：2010-06-23
Applicant: Jean-Jacques Zeiller , Hervé Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
Inventor： Jean-Jacques Zeiller , Hervé Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
IPC: A61K31/216 , C07C67/56 , C07C51/47 , A61K31/192 , A61P3/06 , A61P3/10 , A61P9/10
CPC classification number: C07C59/68 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/736
Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
Abstract translation: 本发明涉及式I的丁烯酸衍生物：其中R，R 1，R 2和R 3如说明书中所定义，以及其制备方法，包含它们的药物组合物及其用于治疗的用途 血脂异常，动脉粥样硬化和糖尿病。
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4.发明授权公开(公告)号：US07678831B2
公开(公告)日：2010-03-16
申请号：US11579362
申请日：2005-04-06
Applicant: Jean Jacques Zeiller , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
Inventor： Jean Jacques Zeiller , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
CPC classification number: C07D277/24 , C07D213/30 , C07D213/50 , C07D213/64 , C07D213/65 , C07D213/89 , C07D215/14 , C07D215/20 , C07D217/02 , C07D231/12 , C07D231/28 , C07D239/52 , C07D241/44 , C07D249/08 , C07D261/08 , C07D263/57 , C07D265/38 , C07D277/66 , C07D285/06 , C07D295/096 , C07D307/42 , C07D307/46 , C07D307/60 , C07D307/79 , C07D307/80 , C07D307/82 , C07D307/86 , C07D307/91 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/22 , C07D311/24 , C07D311/30 , C07D311/54 , C07D311/56 , C07D311/74 , C07D311/76 , C07D317/64 , C07D327/04 , C07D333/22 , C07D333/28 , C07D333/56 , C07D409/04 , C07D471/04
Abstract: Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the preparation of these compounds. Compounds of formula (I) are activators of PPARα and PPARα isoforms.
Abstract translation: 式（I）的化合物：其中R，R 1和R 2如说明书中所定义，其用于治疗血脂异常，动脉粥样硬化和糖尿病的药物组合物，以及包含它们的药物组合物。 制备这些化合物的方法。 式（I）化合物是PPARα和PPARα同工型的活化剂。
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5.发明申请公开(公告)号：US20080032982A1
公开(公告)日：2008-02-07
申请号：US11579362
申请日：2005-04-06
Applicant: Jean Zeiller , Herve Dumas , Valerie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gerard Ferrand , Yves Bonhomme
Inventor： Jean Zeiller , Herve Dumas , Valerie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gerard Ferrand , Yves Bonhomme
IPC: A61K31/192 , A61K31/352 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/5375 , A61P3/00 , A61P9/10 , C07C59/215 , C07D213/55 , C07D261/08 , C07D277/24 , C07D295/14 , C07D311/30 , C07D333/24
CPC classification number: C07D277/24 , C07D213/30 , C07D213/50 , C07D213/64 , C07D213/65 , C07D213/89 , C07D215/14 , C07D215/20 , C07D217/02 , C07D231/12 , C07D231/28 , C07D239/52 , C07D241/44 , C07D249/08 , C07D261/08 , C07D263/57 , C07D265/38 , C07D277/66 , C07D285/06 , C07D295/096 , C07D307/42 , C07D307/46 , C07D307/60 , C07D307/79 , C07D307/80 , C07D307/82 , C07D307/86 , C07D307/91 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/22 , C07D311/24 , C07D311/30 , C07D311/54 , C07D311/56 , C07D311/74 , C07D311/76 , C07D317/64 , C07D327/04 , C07D333/22 , C07D333/28 , C07D333/56 , C07D409/04 , C07D471/04
Abstract: Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the preparation of these compounds. Compounds of formula (I) are activators of PPARα and PPARα isoforms.
Abstract translation: 式（I）的化合物：其中R 1，R 1和R 2 2如说明书中所定义，其用于治疗血脂异常，动脉粥样硬化和糖尿病的用途 ，包含它们的药物组合物，和。 制备这些化合物的方法。 式（I）化合物是PPARα和PPARα同工型的活化剂。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20060178434A1
公开(公告)日：2006-08-10
申请号：US10566995
申请日：2004-07-14
Applicant: Jean-Jacques Zeiller , Herve Dumas , Valerie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gerard Ferrand , Yves Bonhomme
Inventor： Jean-Jacques Zeiller , Herve Dumas , Valerie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gerard Ferrand , Yves Bonhomme
IPC: A61K31/235 , A61K31/22 , C07C69/73 , C07C69/76
CPC classification number: C07C59/68 , C07C59/64 , C07C69/732 , C07C69/734 , C07C69/736
Abstract: The present invention relates to butenoic acid derivatives of the formula I: in which R, R1, R2 and R3 are as defined in the description, and also to processes for the preparation thereof, to pharmaceutical compositions comprising them and to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes.
Abstract translation: 本发明涉及式I的丁烯酸衍生物：其中R 1，R 2，R 2和R 3均如 描述，以及其制备方法，包含它们的药物组合物及其用于治疗血脂异常，动脉粥样硬化和糖尿病的用途。
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7.发明申请公开(公告)号：US20090286776A1
公开(公告)日：2009-11-19
申请号：US12507880
申请日：2009-07-23
Applicant: Jean Jacques ZEILLER , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
Inventor： Jean Jacques ZEILLER , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
IPC: A61K31/5375 , C07C57/03 , A61K31/192 , C07D307/91 , A61K31/343 , C07D311/04 , A61K31/352 , C07C69/76 , A61K31/235 , C07D213/62 , A61K31/44 , C07D239/02 , A61K31/505 , C07D249/08 , A61K31/4196 , C07D265/30 , C07D215/00 , A61K31/47 , A61P9/00 , A61P9/10 , A61P3/10
CPC classification number: C07C59/68 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/738 , C07C205/37 , C07C323/19 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D277/24 , C07D295/096 , C07D333/16 , C07D333/56
Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and processes for the preparation of these compounds.
Abstract translation: 式（I）的化合物：其中R，R 1，R 2和R 3如说明书中所定义，其用于治疗血脂异常，动脉粥样硬化和糖尿病的药物组合物，包含它们的药物组合物，以及制备这些化合物的方法 。
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8.发明授权公开(公告)号：US07465752B2
公开(公告)日：2008-12-16
申请号：US11568598
申请日：2005-04-06
Applicant: Jean Jacques Zeiller , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
Inventor： Jean Jacques Zeiller , Hervè Dumas , Valérie Guyard-Dangremont , Isabelle Berard , Francis Contard , Daniel Guerrier , Gérard Ferrand , Yves Bonhomme
IPC: A61K31/38 , A61K31/235 , A61K31/19 , C07D227/04 , C07C69/76 , C07C59/54
CPC classification number: C07C69/734 , C07C51/09 , C07C59/68 , C07C67/343 , C07D277/24 , C07D333/16 , C07D333/56
Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
Abstract translation: 式（I）化合物：其中R，R 1，R 2和R 3如说明书中所定义，其用于治疗血脂异常，动脉粥样硬化和糖尿病的药物组合物及其制备方法 这些化合物。
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公开(公告)号：US20080119459A1
公开(公告)日：2008-05-22
申请号：US11908712
申请日：2006-02-16
Applicant: Bruno Roux , Isabelle Berard
Inventor： Bruno Roux , Isabelle Berard
IPC: A61K31/55 , C07D211/06 , A61K31/445 , A61K31/47 , C07D223/04
CPC classification number: C07D295/155 , C07D211/52 , C07D211/62 , C07D217/04
Abstract: Compounds of the formula (I), in which the radicals R1 to R3 and AR are as defined in the description, processes for the preparation thereof, the use thereof in the treatment of cardiovascular diseases, and pharmaceutical compositions comprising them.
Abstract translation: 其中基团R 1至R 3和AR的式（I）化合物如说明书中所定义，其制备方法，其在 心血管疾病的治疗和包含它们的药物组合物。
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公开(公告)号：US20080004315A1
公开(公告)日：2008-01-03
申请号：US11572663
申请日：2005-06-28
Applicant: Didier Roche , Bruno Roux , Isabelle Berard
Inventor： Didier Roche , Bruno Roux , Isabelle Berard
IPC: A61K31/445 , A61K31/155 , A61P3/10 , C07C279/18 , C07D221/00 , C07D207/00 , A61P9/00 , A61K31/40
CPC classification number: C07C279/18 , C07D295/215
Abstract: Compounds of the formula (I): in which the radicals R and R1 to R10 are as defined in the description, processes for the preparation of them, use thereof for the treatment of cardiovascular diseases, and pharmaceutical compositions comprising them.
Abstract translation: 式（I）的化合物：其中基团R和R 1至R 10如在说明书中所定义，其制备方法，其用途 心血管疾病的治疗和包含它们的药物组合物。
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